Results: A meta-analysis of RCTs indicated that supplementation with vitamin D 3 had a significant and positive effect in the raising of serum 25(OH)D concentrations compared with the effect of vitamin D 2 ( P = 0.001). The Cochrane Clinical Trials Registry, International Standard Randomized Controlled Trials Number register, and were also searched for any unpublished trials. Objective: The objective of this article was to report a systematic review and meta-analysis of randomized controlled trials (RCTs) that have directly compared the effects of vitamin D 2 and vitamin D 3 on serum 25(OH)D concentrations in humans.ĭesign: The ISI Web of Knowledge (January 1966 to July 2011) database was searched electronically for all relevant studies in adults that directly compared vitamin D 3 with vitamin D 2. Background: Currently, there is a lack of clarity in the literature as to whether there is a definitive difference between the effects of vitamins D 2 and D 3 in the raising of serum 25-hydroxyvitamin D.
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